In the current issue of debate about marijuana laws and interest in marijuana as medicine one issue remains unresolved: Does heavy, frequent, or prolonged use of cannabis lead to a deterioration in cognitive function that persists well beyond any period of acute intoxication? Is the functioning of the brain altered in the long term? With over 7 million people using cannabis weekly and the potential for increased physician recommendations for select patients to use cannabis therapeutically, answers to these questions are of significant public concern. …